Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains
Identifieur interne : 000074 ( France/Analysis ); précédent : 000073; suivant : 000075Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains
Auteurs : Marie-Pierre Egloff [France] ; Hélène Malet [France] ; Akos Putics [Allemagne] ; Maarit Heinonen [Finlande] ; Hélène Dutartre [France] ; Antoine Frangeui [France] ; Arnaud Gruez [France] ; Valérie Campanacci [France] ; Christian Cambillau [France] ; John Ziebuhr [Allemagne, Royaume-Uni] ; Tero Ahola [Finlande] ; Bruno Canard [France]Source :
- Journal of virology [ 0022-538X ] ; 2006.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Macro domains constitute a protein module family found associated with specific histones and proteins involved in chromatin metabolism. In addition, a small number of animal RNA viruses, such as corona- and toroviruses, alphaviruses, and hepatitis E virus, encode macro domains for which, however, structural and functional information is extremely limited. Here, we characterized the macro domains from hepatitis E virus, Semliki Forest virus, and severe acute respiratory syndrome coronavirus (SARS-CoV). The crystal structure of the SARS-CoV macro domain was determined at 1.8-Å resolution in complex with ADP-ribose. Information derived from structural, mutational, and sequence analyses suggests a close phylogenetic and, most probably, functional relationship between viral and cellular macro domain homologs. The data revealed that viral macro domains have relatively poor ADP-ribose 1"-phosphohydrolase activities (which were previously proposed to be their biologically relevant function) but bind efficiently free and poly(ADP-ribose) polymerase 1-bound poly-(ADP-ribose) in vitro. Collectively, these results suggest to further evaluate the role of viral macro domains in host response to viral infection.
Affiliations:
- Allemagne, Finlande, France, Royaume-Uni
- Bavière, District de Basse-Franconie, Provence-Alpes-Côte d'Azur, Uusimaa
- Helsinki, Marseille, Wurtzbourg
- Université d'Helsinki
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Pascal:06-0412132Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains</title>
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<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ziebuhr, John" sort="Ziebuhr, John" uniqKey="Ziebuhr J" first="John" last="Ziebuhr">John Ziebuhr</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Virology and Immunology, University of Wilrzburg, Versbacher Strasse 7</s1>
<s2>97078 Würzburg</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Basse-Franconie</region>
<settlement type="city">Wurtzbourg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Centre for Cancer Research and Cell Biology, School of Biomedical Sciences, The Queen's University of Belfast, 97 Lisbum Rd</s1>
<s2>Belfast BT9 7BL</s2>
<s3>GBR</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Belfast BT9 7BL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ahola, Tero" sort="Ahola, Tero" uniqKey="Ahola T" first="Tero" last="Ahola">Tero Ahola</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Program in Cellular Biotechnology, Institute of Biotechnology, University of Helsinki, P.O. Box 56, Viikinkaari 9</s1>
<s2>00014 Helsinki</s2>
<s3>FIN</s3>
<sZ>4 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>00014 Helsinki</wicri:noRegion>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Canard, Bruno" sort="Canard, Bruno" uniqKey="Canard B" first="Bruno" last="Canard">Bruno Canard</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
<imprint><date when="2006">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ADP</term>
<term>Microbiology</term>
<term>Virology</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>ADP</term>
<term>Microbiologie</term>
<term>Virologie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Macro domains constitute a protein module family found associated with specific histones and proteins involved in chromatin metabolism. In addition, a small number of animal RNA viruses, such as corona- and toroviruses, alphaviruses, and hepatitis E virus, encode macro domains for which, however, structural and functional information is extremely limited. Here, we characterized the macro domains from hepatitis E virus, Semliki Forest virus, and severe acute respiratory syndrome coronavirus (SARS-CoV). The crystal structure of the SARS-CoV macro domain was determined at 1.8-Å resolution in complex with ADP-ribose. Information derived from structural, mutational, and sequence analyses suggests a close phylogenetic and, most probably, functional relationship between viral and cellular macro domain homologs. The data revealed that viral macro domains have relatively poor ADP-ribose 1"-phosphohydrolase activities (which were previously proposed to be their biologically relevant function) but bind efficiently free and poly(ADP-ribose) polymerase 1-bound poly-(ADP-ribose) in vitro. Collectively, these results suggest to further evaluate the role of viral macro domains in host response to viral infection.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Finlande</li>
<li>France</li>
<li>Royaume-Uni</li>
</country>
<region><li>Bavière</li>
<li>District de Basse-Franconie</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>Uusimaa</li>
</region>
<settlement><li>Helsinki</li>
<li>Marseille</li>
<li>Wurtzbourg</li>
</settlement>
<orgName><li>Université d'Helsinki</li>
</orgName>
</list>
<tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Egloff, Marie Pierre" sort="Egloff, Marie Pierre" uniqKey="Egloff M" first="Marie-Pierre" last="Egloff">Marie-Pierre Egloff</name>
</region>
<name sortKey="Cambillau, Christian" sort="Cambillau, Christian" uniqKey="Cambillau C" first="Christian" last="Cambillau">Christian Cambillau</name>
<name sortKey="Campanacci, Valerie" sort="Campanacci, Valerie" uniqKey="Campanacci V" first="Valérie" last="Campanacci">Valérie Campanacci</name>
<name sortKey="Canard, Bruno" sort="Canard, Bruno" uniqKey="Canard B" first="Bruno" last="Canard">Bruno Canard</name>
<name sortKey="Dutartre, Helene" sort="Dutartre, Helene" uniqKey="Dutartre H" first="Hélène" last="Dutartre">Hélène Dutartre</name>
<name sortKey="Frangeui, Antoine" sort="Frangeui, Antoine" uniqKey="Frangeui A" first="Antoine" last="Frangeui">Antoine Frangeui</name>
<name sortKey="Gruez, Arnaud" sort="Gruez, Arnaud" uniqKey="Gruez A" first="Arnaud" last="Gruez">Arnaud Gruez</name>
<name sortKey="Malet, Helene" sort="Malet, Helene" uniqKey="Malet H" first="Hélène" last="Malet">Hélène Malet</name>
</country>
<country name="Allemagne"><region name="Bavière"><name sortKey="Putics, Akos" sort="Putics, Akos" uniqKey="Putics A" first="Akos" last="Putics">Akos Putics</name>
</region>
<name sortKey="Ziebuhr, John" sort="Ziebuhr, John" uniqKey="Ziebuhr J" first="John" last="Ziebuhr">John Ziebuhr</name>
</country>
<country name="Finlande"><region name="Uusimaa"><name sortKey="Heinonen, Maarit" sort="Heinonen, Maarit" uniqKey="Heinonen M" first="Maarit" last="Heinonen">Maarit Heinonen</name>
</region>
<name sortKey="Ahola, Tero" sort="Ahola, Tero" uniqKey="Ahola T" first="Tero" last="Ahola">Tero Ahola</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Ziebuhr, John" sort="Ziebuhr, John" uniqKey="Ziebuhr J" first="John" last="Ziebuhr">John Ziebuhr</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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